目的 研究夏至草(Lagopsis supina)全草的化学成分。方法 采用硅胶、Sephadex LH-20柱色谱和半制备HPLC等色谱方法对夏至草化学成分进行分离和纯化,结合其理化性质及MS、NMR等谱学数据鉴定化合物的结构。结果 从夏至草提取物正己烷、二氯甲烷、水萃取部位分离并鉴定了13个化合物,分别是叶绿醇(1)、胡萝卜苷(2)、8-O-乙酰哈巴苷(3)、antirrinoside(4)、筋骨草苷(5)、益母草苷A(6)、哈巴苷(7)、1-O-咖啡酰基-β-D-吡喃葡萄糖(8)、1-O-对香豆酰基-β-D-葡萄糖(9)、2-hydroxy-5-(2-hydroxyethyl)phenyl-1-O-β-D-glucopyranoside(10)、methyl 2-O-β-D-glucopyranosylbenzoate(11)、腺苷(12)和蔗糖(13)。结论 化合物1,3~13为首次从夏至草属植物中分离得到。
Abstract
OBJECTIVE To investigate the chemical constituents from the whole plants of Lagopsis supina. METHODS The compounds were isolated and purified by various column chromatography, and their structures were identified based on their physiochemical properties and spectroscopic data. RESULTS Thirteen compounds were isolated from the n-hexane, dichloromethane, and water extracts of the whole plants of Lagopsis supina by using various chromatographic methods. Their structures were identified as phytol(1), daucosterol(2), 8-O-acetylharpagide(3), antirrinoside(4), ajugoside(5), ajugol(6), harpagide(7), 1-O-caffeoyl-β-D-glucopyranose(8), 1-O-coumaroyl-β-D-glucopyranose(9), 2-hydroxy-5-(2-hydroxyethyl)phenyl-1-O-β-D-glucopyranoside(10), methyl 2-O-β-D-glucopyranosylbenzoate(11), adenosine(12), and sucrose(13), respectively. CONCLUSION Compounds 1 and 3-13 are isolated from the plants of Lagopsis genus for the first time.
关键词
夏至草属 /
夏至草 /
环烯醚萜苷 /
酚苷 /
8-O-乙酰哈巴苷 /
筋骨草苷 /
益母草苷A /
哈巴苷
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Key words
Lagopsis /
Lagopsis supina /
iridoid glycoside /
phenolic glycoside /
8-O-acetylharpagide /
ajugoside /
ajugol /
harpagide
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中图分类号：
R284
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参考文献
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脚注
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基金
国家“重大新药创制”科技重大专项资助项目(2013ZX09402201001);教育部新世纪优秀人才支持计划资助项目(NCET-13-0693)
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